[2] Ferguson made his professional debut in 2015, with the Arizona League Dodgers and spent the whole season there, pitching to a 0–3 record and 8.59 ERA in 14+2⁄3 innings.

[3] In 2016, he played for the Arizona League Dodgers, Ogden Raptors and Great Lakes Loons, compiling a 3–4 record and 2.31 ERA in 14 games (12 starts).

[12] In mid-September, he suffered damage to his ulnar collateral ligament and underwent Tommy John surgery, for the second time in his life.

[12] On January 13, 2023, he agreed to a one-year, $1.1 million contract with the Dodgers, avoiding salary arbitration[15] and he pitched in 68 games (including seven starts as an opener) with a 7–4 record and 3.43 ERA during the 2023 season.

On July 30, 2024, the Yankees traded Ferguson to the Houston Astros in exchange for pitcher Kelly Austin and cash considerations.

In the 2024 American League Wild Card Series (ALWCS) versus the Detroit Tigers, he made one scoreless appearance, getting one out (1⁄3 inning).