Calgranulin

Calgranulin is an S100 calcium-binding protein that is expressed in multiple cell types, including renal epithelial cells and neutrophils.

The proteins S100A8 and S100A9 form a heterodimer called calprotectin.

Some in vitro evidence suggests that calgranulin can inhibit the precipitation of calcium oxalate in a urine-like environment at calgranulin concentrations below physiological concentrations.

[1] Thus, it may also function in vivo as an inhibitor of calcium oxalate kidney stone formation.

However, the role of calgranulin in the stone formation process has not been evaluated.