Neurogranin has recently been found in aortic endothelial cells and cardiomyocytes.

[5][6] Neurogranin is the main postsynaptic protein regulating the availability of calmodulin, binding to it in the absence of calcium.

One study tells of potential link of neurogranin gene to the heightened risk of schizophrenia in males,[8] another study gives evidence of lowered neurogranin immunoreactivity in the brains of people suffering from schizophrenia.

[9] Neurogranin concentration in cerebrospinal fluid (CSF) is further discussed as marker for synaptic dysfunction in age-related neurodegeneration.

[11][12] Especially, the ratio of CSF neurogranin trunc P75 and the beta-secretase BACE1 is suggested as a potential marker for cognitive deterioration in the progress of Alzheimer's disease.