New district boundaries drawn by the 2020 California Citizens Redistricting Commission went into effect for the 2022 elections.

The 12th State Senate district now encompasses the southeastern Central Valley and the northwestern corner of the Mojave Desert; and it includes portions of Fresno County, Kern, and Tulare Counties, including the following cities:[1]: 70 The district also includes the Tule River Indian Reservation, Cold Springs Rancheria, Big Sandy Rancheria, and Table Mountain Rancheria.

[1]: 70  The neighboring districts 14 and 16 were specifically drawn to allow Latino voters to elect state senators of their choice in order to comply with the Voting Rights Act,[1]: 45  which affected the western border of District 12.

The rural district was primarily agricultural and heavily Latino.

[5] Due to redistricting, the 12th district has been moved around different parts of the state.