California's 22nd senatorial district is one of 40 California State Senate districts.

It is currently represented by Democrat Susan Rubio of Baldwin Park.

The district encompasses eastern San Gabriel Valley and the Pomona Valley in Los Angeles County, including El Monte, West Covina, Covina, Duarte, Baldwin Park, Irwindale, Vincent, Azusa, San Dimas, La Verne, and Pomona; as well as Montclair, Chino, and Ontario in the southwestern corner of San Bernardino County.