The California University of Science and Medicine (CUSM) is a private accredited medical school located in Colton, California/San Bernardino, San Bernardino County, United States.

CUSM received preliminary LCME accreditation in February 2018, and enrolled students for classes conferring an M.D.

[2] The new CUSM campus, completed in 2020, has two lecture halls, nine college rooms, 15 clinical skills rooms and three labs.

[3] More than 2,400 students applied to CUSM's inaugural class, with 64 students enrolling in the class of 2022.

[5] The California University of Science and Medicine currently is affiliated with Arrowhead Regional Medical Center as the primary teaching hospital.