The Calle-Calle and Santa Elvira bridges crosses the river in the city of Valdivia.

The city of Valdivia obtains most of its water supply from Calle-Calle River near Cuesta Soto.

Decreasing precipitation has caused the river to be contaminated with saline water from the coast.

[4] Estimations indicate that whenever the sum of the water discharge of Cruces and Calle-Calle rivers falls below 74 m3/s (2,600 cu ft/s) saltwater reaches the supply site at Cuesta Soto.

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