The simple-station Calle 22 is part of the TransMilenio mass-transit system of Bogotá, Colombia, opened in the year 2000.

The station is located in the heart of downtown Bogotá, specifically on Avenida Caracas between Calles 22 and 24.

In 2000, phase one of the TransMilenio system was opened between Portal de la 80 and Tercer Milenio, including this station.

It services the demand of the passengers of downtown Bogotá, specifically the neighborhoods of Santa Fé and Alameda.

Four months after the opening of the TransMilenio, during the national strike of April 9, 2001, the first attacks against the system occurred.