Chimombo was a member of the Cabinet of Malawi as a National Coordinator of Maternal, Infant and Child Health and HIV/Nutrition/Malaria and Tuberculosis.

She has served as a member of the Pan-African Parliament, and as the Malawi Minister of Tourism, Wildlife and Culture.

[5] At one point, Mutharika and Callista displayed their joy by taking it to the dance floor where his children, family members and guests spent almost 20 minutes dancing to an interlude of music that turned the whole event into a frenzy of excitement and jubilation.

[7] She stated that Banda's supporters were tantalizing themselves by drawing parallels with Liberian first female President Ellen Johnson Sirleaf.

[8] The First Lady's Foundation sought to promote the advancement of women and vulnerable populations in all sectors of our rapidly changing and developing society.

[10] She has also been appointed to the Malawi Cabinet as of September 8, 2011 as the National Coordinator of Maternal, Infant and Child Health and HIV/Nutrition/Malaria and Tuberculosis.

[10] On September8th, 2011, an online newspaper, Maravi post and the Nyasatimes Newspapers reported that Callista Mutharika had been either accidentally or purposefully listed as Vice President of Malawi on the official Malawi government website and included screenshots.

Callista Mutharika created tension over a speech in which she criticized local NGO's that, "supported homosexuality and disturbed peace".