Callon of Epidaurus

2nd century BC) was an intersex person, whose medical treatment is the first recorded example of gender affirmation surgery.

[4][5] Assigned female at birth, he is described by Diodorus Siculus as an orphan, who was forced to marry when he "came of age" and lived with his husband for two years.

The apothecary charged twice the amount for his services since "he had received a female invalid and made her into a healthy young man".

[7] For Luc Brisson the androgyny of Callon, and also Diophantus of Abae, is a natural phenomenon that can be solved by surgical intervention.

[9] Shaun Tougher observes that both Callon and Diophantus' lives are found "in the context of the Hellenistic east".