A native of Port St. Joe, Florida, Pryor attended the local high school where he was a three-sport athlete in football, basketball and baseball.

During his tenure, he accumulated 218 total tackles, including 11 for losses, two sacks, seven interceptions, and nine forced fumbles.

On December 29, 2013, Pryor announced that he would forgo his remaining eligibility at Louisville and enter the 2014 NFL draft.

[4] Pryor was selected by the New York Jets as the 18th pick of the first round of the 2014 NFL draft.

[7][8] On June 1, 2017, Pryor was traded to the Cleveland Browns in exchange for Demario Davis.