[9] Akers first 100-yard game came against Miami (FL), where he rushed for 129 yards on 14 carries in a 24–20 loss.

[12] Against Louisiana–Monroe in the final regular season game, Akers rushed for 117 yards on 19 carries and two touchdowns.

[14] Akers was named Third-Team All-Atlantic Coast Conference (ACC) at the end of the season.

In Florida State's second game of the season, Akers rushed for 193 yards on 36 carries and a pair of touchdowns.

[21] In Akers final game against Florida, he had 17 rush attempts for 102 yards and a touchdown in a 40–17 loss.

[22] On December 14, 2019, Akers announced he would be skipping the Sun Bowl to enter the 2020 NFL draft.

[25] Akers was considered the sixth-best running back to enter the 2020 NFL Draft and was a projected second-round pick.

[29] In Week 11 against the Tampa Bay Buccaneers, Akers scored his first career touchdown on a four-yard reception in the third quarter in a 27–24 victory.

[30][31] In Week 14 against the New England Patriots, Akers rushed for 171 yards on 29 attempts which marked the sixth-most rushing yards by any NFL player in a single game during the 2020 season and fourth-most by a Rams rookie in a single game in franchise history.

[35] In the Divisional Round of the playoffs against the Green Bay Packers, Akers rushed for 90 yards and a touchdown during the 32–18 loss.

[36] On July 20, 2021, Akers tore his Achilles tendon while working out shortly before the start of training camp.

[45] Akers began the season as the Rams' starting running back in Week 1 at the Seahawks.

He carried the ball 22 times for 29 yards and scored on a 1-yard touchdown run in the fourth quarter of Los Angeles's 30–13 season-opening win.

For unspecified reasons, Akers was inactive before the Week 2 game against the 49ers, with Kyren Williams making the start at running back.