Lewis received scholarship offers to play college football at Toledo and Western Michigan but ultimately attended the University at Buffalo, where he played on the Buffalo Bulls football team from 2015 to 2018.

[1] As a freshman on November 11, 2015, Lewis returned an interception 68 yards for a touchdown during a game against Northern Illinois.

[3] On September 11, 2018, he was named the Mid-American Conference (MAC) East Defensive Player of the Week after recording two interceptions in a game against Temple.

[4] As a senior in 2018, despite missing time with a high-ankle sprain, Lewis led the team in interceptions and passes defended and was named to the All-MAC Second-team Defense.

[3][5] Lewis was signed by the Buffalo Bills as an undrafted free agent following the conclusion of the 2019 NFL draft.