Cambio 16 is a Spanish language monthly current affairs magazine published in Madrid, Spain, by "Group 16".

The first director of Cambio 16 was Juan Tomás de Salas from 1972 until 1976 when he was replaced by José Oneto who ran the magazine until 1986.

[15] The company's economic crisis worsened and in September 1995 Laca reached a compromise with the businessman José Luis Domínguez to sell him the majority of the shares in the group, which until then controlled three publications: Cambio 16, Diario 16 and Motor 16.In August 1996, Dominguez was forced to continue firing.

[18] After Juan Tomas de Salas died of cancer on 22 August 2000, aged 62, the magazine was re-launched after going bankrupt.

It was in the midst of this readjustment, in 2001, that Cambio 16's Basque delegate, Gorka Landaburu, was injured in an attack by the terrorist organisation ETA when he opened a parcel bomb, suffering serious injuries all over his body, losing part of his hands and the sight in his left eye.

[20] To combat the decline of newspapers threatened by the arrival of digital media, a new editorial and business model is proposed: The content has been revamped.