[4] As of 2023[update], the mall is anchored by TJ Maxx.

Previous anchors include department stores Filene's, Lechmere, Macy's, Macy's Home and Children's, Best Buy and Sears.

The center was an outgrowth of the 1978 East Cambridge Riverfront Plan,[5] which sought to revitalize the then-industrial district between Monsignor O'Brien Highway, Cambridge Parkway, and First Street.

The east end of CambridgeSide is near the Museum of Science and the north end of CambridgeSide is near the MBTA Lechmere station on the Green Line E branch.

[8] On May 14, 2022, it was announced that Best Buy would be closing on June 4, 2022 which will leave TJ Maxx as the only anchor left.