The company peaked at 400 employees during the COVID-19 pandemic in the United States, when social distancing during 2020 and 2021 made the service a convenient way to send unique best wishes to friends and family; by July 2023, staff had fallen to 33 people.

In April 2016, Blencowe got NFL player Cassius Marsh to record himself congratulating his friend on the birth of his son.

[10] The site grew during the height of the COVID-19 pandemic in the United States (c. 2020 – c. 2021), as it accommodated social distance restrictions, for both clients and celebrities, in place in during that time.

[12] In July 2020 the site launched Promotional Cameos, a premium priced service for businesses to buy celebrity endorsements.

[17] Following the end of the pandemic, and the associated inflation that led to interest rate hikes, Cameo went through a series of layoffs: it cut 87 people in May 2022;[17] a further 80 people in November 2022;[18] and performed a third round of layoffs in July 2023, bringing their number of employees down to 33.

[16] Popularity resurged due to the 2023 SAG-AFTRA strike, with over 2,400 actors joining or rejoining the site, attracting more customers.