He was on the Denver Broncos' Super Bowl 50 championship team when they defeated the Carolina Panthers.

[3] On February 7, 2016, Jefferson was part of the Broncos team that won Super Bowl 50 over the Carolina Panthers by a score of 24–10.

[11][12] Jefferson signed a practice roster contract with the Saskatchewan Roughriders of the Canadian Football League (CFL) on June 26, 2019.

[13] After the CFL canceled the 2020 season due to the COVID-19 pandemic, Jefferson chose to opt-out of his contract with the Roughriders on August 26, 2020.

[14] Jefferson signed with the Conquerors of The Spring League on October 17, 2020,[15] and opted back in to his contract with the Roughriders on January 4, 2021.