[1] Having reached the proper age, he entered the famous Certosa di San Martino in Naples, where some of his relatives had lived as monks in earlier centuries.

At that time, Tutini started his correspondence with Ferdinando Ughelli, a librarian at the Vatican and the famous editor of Italia Sacra, and Bartolomeo Chioccarello, with whom he closely cooperated.

In 1647, he was linked to Matteo Cristiano, a leader during the Neapolitan Republic as well as to the party favoring French intervention under Henry II, Duke of Guise.

These links, and his praise of republicanism, putatively led to the threat of arrest in Naples, and he fled to Rome under the protection of Cardinal Francesco Maria Brancaccio.

[3] Tutini befriended and collaborated with many of the most prominent scholars of his age, including Antonio Amico, Agostino Inveges, Lucas Holstenius and Leo Allatius.