The name of the hotel was taken from that given by 16th century Spaniards to the road that led to the capital of New Spain, today known as Mexico.

Their efforts would be bolstered in 1962 with an affiliation agreement with Western International Hotels (renamed Westin in 1980).

The relationship between Westin and Camino Real established the first internationally backed luxury hotel chain in Mexico and ended 31 years later, in 1993.

In 2000, Camino Real was bought by business group Grupo Empresarial Ángeles for US$252 million.

[2] One Camino Real hotel in Mexico City features a restaurant owned by Masaharu Morimoto.