It is located about 75 km (47 mi) from the Autonomous City of Buenos Aires, on the right-hand margin of the Paraná River.

The Pan-American Highway (Route 9) links Campana to Buenos Aires, Rosario, Córdoba and the north of Argentina.

Campana has been since late 19th century and to a lesser degree today an important shipyard and port for passengers traveling to the remote Ibicuy Islands of the Paraná Delta.

[1] Most of the city's population consists almost entirely by descendants of Italian and Spanish (mostly Galicians) immigrants, although there are other minorities such as Germans, British, French and Roms.

In recent years there has been a slight increase in population from East Asia (China and South Korea) and Latin American countries like Bolivia, Paraguay and Peru.