Jeffery Scott Campbell was born in East Tawas, Michigan, though he has no memories of that city, as his family moved when he was very young to Denver, Colorado, which he regards as his home.

[6] After graduating from high school in Aurora, Colorado, Campbell began doing freelance commercial art jobs.

One issue advertised a talent search for which readers could submit artwork, so Campbell put together a package that included a four-page WildC.A.T.S story and sent it in.

[3] Campbell went on to co-create the teen superhero team Gen13, which debuted in Deathmate Black (September 1993), before going on to star in their own five-issue miniseries in January 1994.

In 1998, Campbell, together with fellow comics artists Joe Madureira and Humberto Ramos, founded the Cliffhanger imprint as part of Wildstorm Productions.

The story, which followed the adventures of a group of female secret agents, made the most of Campbell's talents drawing well-endowed women and dramatic action sequences.

In October 2016, Marvel Comics and New York-based retailer Midtown Comics jointly decided to pull from circulation Campbell's variant cover of the first issue of The Invincible Iron Man, produced exclusively for that store, after previews of the cover were criticized for sexualizing the depicted character, 15-year-old Riri Williams.

[10][11] The cover depicted the character, a teenaged MIT engineering student who reverse engineered one of Iron Man's armored suits to wear herself, in a midriff-baring crop top, in contrast to the more modest way in which artist Stefano Caselli depicted the character in the book's interior art.

Campbell called the decision "unfortunate," explained that his rendition of the character was intended to depict "a sassy, coming-of-age young woman".

Brian Michael Bendis, the writer on the series, was pleased with the decision to pull the cover, saying that while he liked the face Campbell had drawn on Riri when he viewed the art as a work in progress, he disliked the completed art, saying, "Specialty covers are not in my purview and it was being produced separately from the work of the people involved in making the comic.

[13][14] He maintains sharpness of the lead with a Berol Turquoise sharpener, changing them every four to six months, which he finds is the duration of their grinding ability.