Campo de la Cruz (Spanish for "field [or countryside] of the cross") is a municipality and a town in the Colombian department of Atlántico.

By road, Campo de la Cruz is located 80 km to the south of Barranquilla.

Originally a fishing village, it was formally founded in the 17th century during the colonial period as 'Puerto Real de la Cruz'.

Once the town gained independence from the Spanish Empire, the name was changed to its current denomination, Campo de la Cruz.

During the colonial time and the early republican period it was a small but still important fluvial port.