Written by Ciara, LaShawn Daniels, Rodney Jerkins, and 50 Cent, it is the fourth release and official third single from the album (see 2007 in music).

Later, "My Love" was confirmed to be the third US single,[2] while "That's Right" would serve as the third internationally, but "Can't Leave 'em Alone" replaced both songs.

"Can't Leave 'em Alone" is an ode to the hood boys anchored by a pair of verses from 50 Cent, featuring an "easy groove".

Contactmusic.com published "Can't Leave 'em Alone" is a "mouth-watering smouldering smoothed groove", with the reviewer going on to say that it should have been the first single, and that It has "cross over potential that we see from Nelly & Kelly Rowland ["Dilemma"]" and is "simply another Darkchild classic".

[6] Christian Hoard of Rolling Stone published "Ciara's still prone to diva blandness and silly little pop songs, which drags down the 50 Cent feature 'Can't Leave 'em Alone' ".

Despite its lackluster performance at radio, the single was certified gold by the Recording Industry Association of America (RIAA) for sales of over 500,000 digital copies in the United States.

[12] Ciara performed "Can't Leave 'em Alone" with 50 Cent at the 2007 World Music Awards on November 24, 2007.