"Hands Up" is a song by American rapper Lloyd Banks featuring fellow G-Unit member 50 Cent on the chorus.

It was released via G-Unit/Interscope Records on July 25, 2006 digitally and on September 18, 2006 as the lead CD single from his second solo studio album Rotten Apple.

Production was handled by Eminem, Chris Styles and Bang Out, with Luis Resto serving as additional producer.

The accompanying music video, directed by Jessy Terrero, debuted on BET.

It was filmed in an old warehouse, which had been turned into a club, and features cameo appearances from 50 Cent, Tony Yayo and Mobb Deep.