The song was written and produced by Teddy Park and is musically a dance-pop number with the lyrics revolving around the themes of self-confidence and empowerment.

The song was written and produced by Teddy Park, who has worked on 2NE1's previous extended play in 2009 and their single "Try to Follow Me" in February 2010.

[2] The music video for "Can't Nobody" was released on September 12,[3] and the first live stage for the song was broadcast later that night on Inkigayo.

[8] Lee Jong-min of IZM gave "Can't Nobody" an unfavorable review, where he felt that the "unity of the arrangement was a bit unnatural" and more effort was put into trying to make it a hit than originality.

The following week, "Can't Nobody" rose two positions and peaked at number 2, just below the album's other title track "Go Away".

[12] The Korean music video begins with CL singing the intro under a curtain as she pulls the zipper down to reveal her nose and mouth.

In Minzy's verse, the scene moves back and forth from her wearing a studded hoodie and tattoos on her torso while sitting on a boombox, and her in a business suit standing next to a large black dog.