Musically, it is an upbeat urban contemporary and dance pop song that features a hefty amount of saxophones.

The physical format was certified gold by the Recording Industry Association of Japan (RIAJ) for selling over 100,000 units.

Since its release, "Can't Sleep, Can't Eat, I'm Sick" has appeared on several of Amuro's concert tours and subsequent live releases, as well as her greatest hits album Best Fiction (2008), and was re-recorded for her final compilation album Finally (2017).

Following the commercial success of Queen of Hip-Pop (2005), Amuro began working on new music with previous collaborators T.Kura, Michico and Nao'ymt for her eighth studio album, Play (2007).

Directed by longtime collaborator, Masashi Muto,[11] the video focuses entirely on a dance routine.

It is also reminiscent of Kylie Minogue's "Can't Get You Out of My Head" (2001) as a majority of it is filmed in a dark room entirely adorned in lights.

[15] The track appeared on her Past

[1] Tetsuo Hiraga of Hot Express gave the song a glowing review, stating: "It's a great tune that will make your summer even more exciting and dazzling.

"[18] Adam Greenberg of AllMusic compared the song's composition to the works of American recording artist, Jennifer Lopez.

[20] The single stayed in the top twenty one last week, ranking at number nineteen and selling 8,583 copies.