In 2007, about 50 people died when the Cần Thơ Bridge collapsed, causing Vietnam's worst engineering disaster.

During the Vietnam War, Cần Thơ was the home of the ARVN IV Corps capital.

The ARVN 21st division was dedicated to protect the city of Cần Thơ, including the provinces of Chương Thiện (now in Hậu Giang), Bạc Liêu, An Xuyen (Cà Mau), Ba Xuyen (Soc Trang), and Kiên Giang.

South of the National Highway 4 from Cần Thơ to Ba Xuyen province (Soc Trang) were mainly heavily patrolled by ARVN soldiers to prevent route disruption.

The six-lane Saigon–Cần Thơ Expressway is being built in parts [clarification needed] from Hồ Chí Minh City to Mỹ Tho.

[citation needed] From Phú Quốc island, tourists can use the ferry, passenger bus or taxi to transfer to Cần Thơ.

For those who visit, who would ever want to leave.Cần Thơ (shared with Hậu Giang) is famous for its floating markets, especially Cai Rang Floating Market, where people sell and buy things on the river, as well as the bird gardens and the port of Ninh Kiều.

Cần Thơ's climate features two seasons: rainy (from May to November) and dry (from December to April).