Canistota is a city in McCook County, South Dakota, United States.

[6] Canistota is known for chiropractic services, especially the longstanding Ortman Clinic,[7][8][9] which attracts many Amish people from around the Midwest.

[10] Canistota was named after Canastota, New York the home of a railroad official, but misspelled in the application for a post office.

[11] Its location is the northwest corner of Section 34, chosen by the Chicago Northwestern Railroad.

[2] According to the United States Census Bureau, the city has a total area of 0.56 square miles (1.45 km2), all land.

28.5% of all households were made up of individuals, and 13.2% had someone living alone who was 65 years of age or older.

29.5% of all households were made up of individuals, and 18.9% had someone living alone who was 65 years of age or older.