Construction began in 1959 and the site was accepted by NASA to support the Saturn I program in 1963.

LC-37A has never been used, but LC-37B launched seven uncrewed Saturn I flights (1964 to 1965) and was modified and launched two Saturn IB flights (1966 to 1968), including the first (uncrewed) test of the Apollo Lunar Module in space (Apollo 5).

[1] The draft Environmental Impact Statement (EIS) by the Federal Aviation Administration is due in December 2024, with a final study by September 2025.

Boeing turned the Delta IV operations over to United Launch Alliance (ULA) in 2006.

In 2024, after the retirement of the Delta IV Heavy, the FAA initiated an Environmental Impact Statement for potential Starship launch activity from the complex.