The pads were operated by the 45th Space Wing and have supported more than 300 Department of Defense, NASA and commercial missile and rocket launches.

The site was upgraded in the early 1960s to support a variety of more modern ELVs, which were derived from the basic Thor booster.

On 10 September 2011, a Delta II 7920H-10C made the final launch from SLC-17B, carrying NASA's GRAIL spacecraft.

All remaining Delta II launches were made from Vandenberg Air Force Base in California.

At 11:00 UTC (7:00 a.m. EDT) on 12 July 2018, both launch towers had been demolished via controlled demolition to make way for Moon Express to build and test its lunar lander.