In the years 1526 to 1527, Naples endured a siege by the French, a resurgence of the plague, and a volcanic eruption by Vesuvius with its accompanying earthquakes.
[1] On February 5, 1601, the "elect of the city" appointed a committee of twelve lay members, called on the "Deputation" to build of the new chapel.
Centuries later, after the Naples joined the Kingdom of Italy, the chapel was exempted from lists of those religious structures confiscated by the state.
[5] However, the Deputation on June 6, 1646, decided to ask the local painter Massimo Stanzione, to complete the altarapiece of Miracle of the Obsessed, left incomplete by Domenichino.
Ultimately, Stanzione's submission was not acceptable, and they entrusted the work to Jusepe de Ribera, who painted San Gennaro emerges unscathed from the furnace of Cimitile.
Behind the altar, two niches with silver doors donated by Charles II of Spain in 1667 guard the vials of the blood of San Gennaro.
The reliquary bust of Saint Gennaro in gold and silver was made by three goldsmiths Provençal, and donated by Charles II in 1305.
The largest bronze sculptures, including a St Peter and Paul flanking the entrance, were made by Giuliano Finelli, a student of Bernini.