Santa Maria della Sapienza is a Roman Catholic church, located on Via Costantinopoli in central Naples, Italy.

In 1507, the cardinal Oliviero Carafa, archbishop of Naples, began plans for construction at the site a University della Sapienza.

Work only began posthumously on lots purchased from Giovanni Latro, and Giampietro and Marino Stendardo.

The two sculpted roundels in the façade depict busts of Pope Paul IV and his sister Maria.

[1] The church was built in 1625 using designs by Francesco Grimaldi (a Theatine priest), and completed by 1630 by Giovan Giacomo Di Conforto.