In 1722 Ferrante Capponi had the chapel restored again, adding a new altar with polychrome marble and closing it with a wrought iron enclosure which still exists.
A tondo by Pontormo, depicting the Madonna with Child, was perhaps moved in this period from the chapel to the Capponi private palace.
The chapel was built by Brunelleschi in the period in which he was active in the Spedale degli Innocenti, and was still supporting the feasibility of the dome of Santa Maria del Fiore.
The theme, already used for the portico of the Spedale degli Innocenti, was repeated by Brunelleschi with little variants in the Sagrestia Vecchia and the Pazzi Chapel.
At the high altar, enclosed in its original 16th century frame, is the masterwork of the Mannerist painter Pontormo, depicting the Deposition from the Cross, executed from 1525 to 1528.