The Capture of Mannheim was achieved on 2 November 1622 by the Imperial-Spanish army commanded by Johan Tzerclaes, Count of Tilly against the Protestant troops under the Englishman Sir Horace Vere during the Thirty Years' War.

[2] In September 1620, the Imperial-Spanish troops led by the Count of Tilly and Don Gonzalo Fernández de Córdoba invaded and conquered the Lower Palatinate.

The Protestant garrison under Sir Horace Vere held Frankenthal, Mannheim, and Heidelberg, but the rest of the Palatinate fell into Spanish hands.

[2][3] The courage displayed by Horace Vere against great odds was recognised in England, when the General returned early in February 1623, even if his salary and expenses were never paid in full by the treasury.

[2] In 1624, Vere travelled once more to The Hague in order to second Prince Maurice of Orange in the defence of the important fortress of Breda, under siege by the Spaniards under Don Ambrosio Spinola from August.