Delevingne started her acting career with a minor role in the 2012 film adaptation of Anna Karenina by Joe Wright.

This was the beginning of what would turn out to be a longlasting professional relationship with Chanel's head designer and creative director, Karl Lagerfeld.

During New York Fashion Week, she walked for designers including Marc Jacobs, Oscar de la Renta and Marchesa.

[25] She followed this appearance by walking in shows for Sass & Bide, Issa, Preen, Topshop, Mary Katrantzou, Giles, and Matthew Williamson.

For Milan Fashion Week, she walked for Moschino, Emilio Pucci, Ermanno Scervino, Ports 1961, Anteprima, Iceberg, Gabriele Colangelo, Anthony Vaccarello, and Just Cavalli.

[5] During London Fashion Week, she walked for Sister by Sibling, Issa, Topshop, Mulberry, Matthew Williamson, Peter Pilotto, Burberry, and Giles.

After this Delevingne walked in another seven shows at the Milan Fashion Week for Fendi, Ports 1961, DSquared2, Etro, Versace, Iceberg and Pucci.

In Paris, Delevingne walked in eleven shows for Katie Grand's collaboration with Tod's Hogan brand, H&M, Lanvin, Vanessa Bruno, Jean Paul Gaultier, John Galliano, Stella McCartney, Yves Saint Laurent, Chanel, Hakaan and Louis Vuitton.

[39] A month later, she featured in South African group Die Antwoord's music video for their song "Ugly Boy".

[40] Then in December 2014, Delevingne starred in Reincarnation, a short film by Karl Lagerfeld for Chanel alongside Pharrell Williams and Geraldine Chaplin.

[46] She also appeared in advertisements for DKNY (including a menswear campaign),[47][48] Tag Heuer,[49] Penshoppe,[50] Pepe Jeans,[51] Burberry, Alexander Wang,[52] and Mango reuniting with Kate Moss.

[53] Delevingne appeared on a solo cover of Vogue,[9] as well as The Wall Street Journal,[54] and Love alongside Kendall Jenner, among others.

[citation needed] In 2017, Delevingne appeared on the cover of the online magazine The Edit by luxury fashion retailer Net-a-Porter.

[63] In June 2014, Delevingne made her TV debut opposite veteran British actress Sylvia Syms in the final episode of Playhouse Presents.

[73] Rotten Tomatoes' critical consensus reads, "Paper Towns isn't as deep or moving as it wants to be, yet it's still earnest, well-acted, and thoughtful enough to earn a place in the hearts of teen filmgoers of all ages.

"[74] Of Delevingne's performance, Justin Chang of Variety called her "the real find of the film", suggesting that "on the evidence of her work here, this striking actress [sic] is here to stay".

[76] In 2016, Delevingne co-starred as Enchantress, a villainess with magical abilities, in Suicide Squad, an action film based on the DC comic book series of the same name.

Delevingne starred with Dane DeHaan and Rihanna[79] in the Luc Besson film Valerian and the City of a Thousand Planets, an adaptation of the comic book series Valérian and Laureline.

[64][82][83] The Amazon Prime Video fantasy steampunk series Carnival Row features Delevingne in the female lead role (opposite Orlando Bloom) as Vignette Stonemoss, a faerie war refugee.

[88][89] She covered The Strangeloves "I Want Candy" in the mini film called Gang, which was the title of the 2013 A/W Katie Grand Loves Hogan collection and the name of the large-format magazine created to celebrate the collaboration.

[91] The duo performed the song before a live audience for the Chanel show at the Park Avenue Armory in New York City in March 2015.

[96][97] In December 2022, Delevingne featured in her series Planet Sex[98][99] for BBC Three, shown over six episodes, exploring sexuality including her own, in various worldwide locations.

[100][101][102][99] From 11 March 2024, Delevigne will make her stage debut taking over as Sally Bowles in the West End musical Cabaret at the Kit Kat Club (Playhouse Theatre) opposite Luke Treadaway as the Emcee for 12 weeks.

Her DKNY capsule collection featured a variety of sporty street style items ranging from beanie hats to leather jackets.

[110] In 2013, the Evening Standard also ranked her 20th on their "Power 1000" list "because of her domination of the catwalks at London Fashion Week and her huge social media following".

[112] In March 2014, Delevingne was included in The Sunday Times Magazine's "100 Makers of the 21st Century" list of influential British people.

Following the killing of Cecil the lion in 2015, she auctioned off her personal TAG Heuer watch in aid of wildlife conservation, raising £18,600 for WildCRU.

"[137] At the Women in the World summit in October 2015, Delevingne spoke about her battle with depression, which began at age 15,[138] when she discovered her mother's drug addiction.

[140][141] In October 2017, Delevingne alleged that circa 2016, producer Harvey Weinstein sexually harassed her, attempted to kiss her without consent, and propositioned her for a threesome in a hotel room in exchange for a role.

[146][99] She has a tattoo of her lucky number, the Roman numeral XII, on her side under her right arm, and "MADE IN ENGLAND" on the sole of her left foot.