Cardiff and Vale University Health Board (CAVUHB; Welsh: Bwrdd Iechyd Prifysgol Caerdydd a'r Fro) is the local health board of NHS Wales for Cardiff and Vale of Glamorgan, in the south-east of Wales.

Formed on 1 October 2009 through the amalgamation of three NHS organisations in the Cardiff and Vale of Glamorgan area.

[3] The three organisations amalgamated were: Cardiff and Vale NHS Trust, employing 12,000 staff and previously responsibility for hospital services in the Cardiff and Vale of Glamorgan area; Cardiff Local Health Board; and Vale of Glamorgan Local Health Board both responsible for GP, Dental, Optical and pharmacy services.

The Board supports a population of around 445,000 people living in Cardiff and the Vale of Glamorgan.

It oversees seventeen health centres, public health and community care services and also has a range of specialist services used by the whole of Wales, including renal, paediatric, neurology and bone marrow transplantation.