Domenico Ginnasi (19 June 1550 in Castel Bolognese – 12 March 1639, in Rome) was a Cardinal of the Roman Catholic church created by Pope Clement VIII.
One of his younger brothers, Achille Ginnasi (1553-1594), served as Apostolic Protonotary, nominated in 1593, as governor of the County of Castel Bolognese by Clement VIII.
In 1585–86, Domenico was nominated to be governor of the territory of Campagna, which now is mostly the province of Frosinone.
It is said that Domenico ministered the viaticum to a dying Camillus de Lellis on 2 July 1614.
In 1630, Domenico reconstructed the medieval church of Santa Lucia alle Botteghe Oscure that stood near his family's Palace in Central Rome.