He was a relative of cardinals Girolamo Bernerio, Scipione Cobelluzzi and Francesco Cennini de' Salamandri and was a member of the Dominican Order.

He was a professor in the Dominican houses of study in Cremona and other cities in Lombardy.

During the pontificate of Pope Clement VIII, he was named inquisitor in the dioceses of Pavia, Cremona and Milan.

[2] He was appointed bishop of Melfi and Rapolla in 1621 and transferred to the diocese of Como the following year.

He gave up the diocese of Como in 1632–1633 when was Camerlengo of the Sacred College of Cardinals.