She attended the University of Colorado Boulder, the School of the Art Institute of Chicago, and the Clarion West Writers Workshop.

Upon publication of her first novel, Homecoming (Serpent's Tail, 2000), Gussoff was nominated as a Village Voice "Writer on the Verge."

Her third novel, The Birthday Problem, is a post-apocalyptic science fiction story about a communicable mental illness.

Gussoff's other fiction and essays have been anthologized by Serpent's Tail, Seal Press, and Prime Books.

Gussoff also authored the setting chapter of the Gotham Writers' Workshop Writing Fiction: The Practical Guide (Bloomsbury USA).