[2][3] The region's only level I trauma center,[4][5] the hospital operates three medical helicopters (LifeGuard 10, 11, and 12) to provide air ambulance transport, including one in Moneta, one in Christiansburg, and one in Lexington.

In the 1920s and 1930s, its growth was funded through gifts of hundreds of thousands of dollars from David W. Flickwir, a railroad executive and contractor who had married the hospital's nursing superintendent.

The hospital dubbed him its "Greatest Benefactor"; a 1925 building he funded, the Flickwir Memorial Unit, still stands.

[7] In the 21st century, the hospital completed a large expansion project, adding an emergency department, a labor-and-delivery unit, and the Carilion Clinic Children's Hospital, which has a pediatric emergency department.

This article relating to a hospital in Virginia is a stub.