His limited means forced him to leave university early and enter into government service, later ending up working in the administration of the City of Stockholm.
His interest in natural history appears to have come at a more mature age, influenced by a lecture of Linnaeus he attended in Stockholm in 1739.
He also started the publication of Icones insectorum rariorum, a series of detailed but uncommented plates illustrating numerous species of butterflies, left unfinished after the third fascicle (1766) because of Clerck's death.
Because of the exceptionally thorough treatment of the spider species, the scientific names proposed by Clerck in Svenska Spindlar (which were adopted by Carl Linnaeus in his Systema Naturae in 1758 with only minor modifications) had traditionally been recognized by arachnologists as binomial and available, later this was officially recognized in the International Code of Zoological Nomenclature.
[1] This means that in case of doubt the spelling of a spider name as from Clerck's 1757 work has priority over that proposed by Linnaeus in 1758 (an example is Araneus instead of Aranea), and that Clerck's spiders were the first animals in modern zoology to have obtained an available scientific name in the Linnean system.