[4][5] In an interview with Renée Montagne just before his final broadcast on NPR's Morning Edition, Kasell revealed that he knew he would be in radio at a young age.

[6] During his time at the University of North Carolina at Chapel Hill, Kasell helped launch local radio station WUNC with fellow student and future broadcaster Charles Kuralt.

[7] After serving, he worked as an announcer and DJ at radio station WGBR in Goldsboro, North Carolina.

[7] After leaving North Carolina, Kasell first worked as an announcer and DJ at WPIK in Alexandria, Virginia.

He hired Katie Couric, then a student at the University of Virginia, as an intern one summer, thus starting her career in news broadcasting.

Kasell joined National Public Radio's staff as a news announcer for Weekend All Things Considered in 1975.

"[3][10] Prior to October 21, 2017, listeners who won a game on the show could have Kasell record a greeting for their home answering machine or voice mail system.

Stephen Colbert, Katie Couric, Tom Hanks, and President Barack Obama called in to the show to voice their appreciation for Kasell.