As of 2025 Mosley is a main cast member on Fox comedy Going Dutch and the host of the television adaptation of her podcast of the same name, Scam Goddess.

[3][4] Mosley's first lead acting role was on the 2019 Pop series Florida Girls, which was cancelled after one season despite an initial renewal.

After the announcement of her casting, Mosley was the target of racist attacks from fans who saw her as a replacement for Jennette McCurdy's character from the original.

[16] In September 2019, Mosley created the podcast Scam Goddess, produced by Earwolf, where she discusses historic and modern cons with other comedian guests.

[17] The name comes from a moniker given to her by the hosts of The Daily Zeitgeist podcast due to her frequent internet research on scam and fraud cases.

[19][20] Sean Malin of Vulture wrote in positive review, "Mosley is whip-fast with jokes, upstaging and amusing even her funniest guests with zingers.

Mosley wrote a memoir related to the podcast titled Scam Goddess: Lessons from a Life of Cons, Grifts, and Schemes, set for release in September 2024.