In 1997, after appearing on Do or Die's hit single "Po Pimp",[1][2] produced by the Legendary Traxster, Twista signed with Big Beat and Atlantic Records,[3] where he released his third album Adrenaline Rush and formed the group Speedknot Mobstaz, in 1998.

Beginning in 2002, Twista began recording his album Kamikaze with rappers like Kanye West and Ludacris.

[10] Other singles included "Overnight Celebrity" and "So Sexy" (featuring R. Kelly); the album sold around two million copies.

Kamikaze and its singles gave Twista a new level of success and rose his profile significantly within the rap community.Twista's album The Day After was released in 2005.

[citation needed] Twista appeared on the single "Hell No (Leave Home)" from Monica's 2006 album The Makings of Me.

In 2008, Twista launched a new record label called Get Money Gang Entertainment and the album Category F5 with the hit, "Wetter".

The first single from the album, "Make a Movie" produced by the Legendary Traxster, featuring Chris Brown, was released on August 24, 2010.

The album features artists such as Waka Flocka Flame, Raekwon, Tia London, Diddy, Ray J, and others.

Production on the album is mainly by the Legendary Traxster along with Streetrunner, the Kray Twinz, Tight Mike, and No I.D., Twista discussed his new documentary, directed by Vlad Yudin and the making of The Perfect Storm, including his belief that artists need to do more than just record songs and that they need to become more involved with the community around them.

Twista released the mixtape Summer 96 in 2019, this includes the song "Home Invasion" which features Do or Die and produced by Hearon Tracks.

[24] During the holiday season in 2010, Twista and his team Get Money Gang worked together with Chicago Food Bank's Producemobile program to feed hungry people in the community.

[26][better source needed] He teaches a course on concealed carry in Chicago,[27] aiming to using education to combat gun violence.