[1][2] [3] Pabo has been a professor at the Johns Hopkins University School of Medicine (1982–1991) and at the Massachusetts Institute of Technology (1991–2001) and an investigator with the Howard Hughes Medical Institute (1986–2001).
[4] He's been a visiting professor at Caltech, Stanford, Berkeley and Harvard.
[5] At Caltech, he taught a course called “The World in 2050.” [6] In 1991, he used X-ray crystallography to show how Zinc finger nucleases attach to DNA.
In 1994, after moving to the MIT, he showed how zinc fingers could be custom built to grab onto any desired three-base pair DNA sequence.
This was an important step toward building the full library of zinc fingers for all 64 sequences.