Radle’s professional career started out when Leon Russell offered him his entry into the music industry, inviting him out to California.

Radle was best known for his long association with Eric Clapton, starting in 1969 with Delaney and Bonnie and Friends and continuing in 1970 with Derek and the Dominos, recording with drummer Jim Gordon, guitarist Duane Allman, and keyboardist Bobby Whitlock.

Carl also was a member of Colours, a psychedelic cult band from Dot Records for whom he played on the first album and guest appeared on the second.

Over the course of his career, Radle played on a number of gold and platinum singles and albums and garnered the respect of many musicians.

[5] Two albums by Derek and the Dominos, The Layla Sessions: 20th Anniversary Edition and Live at the Fillmore, were released in 1990 and 1994 respectively that posthumously credited Radle.