He played six seasons in Major League Baseball (MLB) from 1961 to 1966 for the Los Angeles Dodgers, St. Louis Cardinals, Houston Colt .45s, Baltimore Orioles and Chicago Cubs.

Warwick batted right-handed but threw left-handed; he stood 5 feet 10 inches (1.78 m) tall and weighed 170 pounds (77 kg).

Warwick made the Dodgers' 28-man early-season roster coming out of spring training in 1961, but was traded to the Cardinals May 30 with shortstop Bob Lillis for third baseman Daryl Spencer.

Back in his native Texas, Warwick became Houston's regular center fielder, starting in 104 games, and his 16 home runs ranked second on the club (to Román Mejías' 24).

His sixth-inning pinch single in Game 1 off Al Downing drove home the go-ahead run in the Cardinals' 9–5 triumph.