Jacobi was a prominent member of the somatic school of psychiatry in Germany, believing that mental disorders were largely due to organic factors.
Jacobi was influenced by the work of Philippe Pinel and William Tuke regarding a "non-restraint policy" for patients, and tried to introduce this reform in Germany.
On the 50th anniversary of his doctorate in 1857, a festival was held in his honor, attended by distinguished men from England and France as well as from every part of Germany.
At this festival, an association was organized called the Jacobi foundation, for the improvement of physicians, officers, nurses, and attendants in the care of the insane.
With Christian Friedrich Nasse, he was co-founder of Zeitschrift für Heilung und Beurtheilung krankhafter Seelenstörungen, a journal dealing with the analysis and treatment of mental disorders.