[2] She made her film debut in 1998 at age 19 in director Hervé Palud’s Mookie, a French comedy set in Mexico.

That same year, she acted in her first supporting role on Mexican television in the telenovela Gotita de amor (Droplet of Love).

Her film career has included starring roles in the 2017 thriller Curse of the Mayans (Spanish title: Xibalba, the name of the Mayan underworld); the 2012 American Western The Man Who Shook the Hand of Vicente Fernandez, alongside Ernest Borgnine in his final role; and in Olvidados (Forgotten), a 2013 historical drama about Operation Condor which she also co-wrote and produced.

In 2022, she returned to television in Season 3 of the Telemundo/Netflix series La Reina del Sur, where she was featured in a recurring role as Karen Chacón.

[4] Ortiz was accused in 2017 by journalist Christoph Reuter in Der Spiegel of engaging in Russian propaganda in relation to the Syrian Civil War,[5] for her participation as a foreign celebrity in chaperoned tours of Syria.