Carlisle is a town located northwest of Boston in Middlesex County, Massachusetts, United States.

Carlisle became a district of Concord in 1780 and was incorporated as a town by an act of the legislature in 1805.

Great Brook Farm is also the site of one of the premiere cross-country ski touring centers in New England.

[3] On the east end of town there is an auto body shop and the former (closed in 2012) Blue Jay Recording Studio, where artists such as the Platters, Aerosmith, Aimee Mann, Amy Grant, Alice Cooper, Boston, John Williams and the Boston Pops, Buckwheat Zydeco, Billy Joel, Lauryn Hill, Rihanna, Roy Orbison, k. d. lang, Pat Metheny, Yo Yo Ma, Carly Simon, the Pussycat Dolls, Genesis and Lady Gaga have recorded.

[9] Carlisle Old Home Day[10] has been held for over 100 years on the weekend prior to the Fourth of July as a free public event with family-friendly games and activities.

It borders the towns of Concord, Acton, Westford, Chelmsford, Billerica, and Bedford.

Besides town-owned land overseen by the town's Conservation Committee, Carlisle is home to the Carlisle Conservation Foundation, Great Brook Farm State Park, and a portion of the Great Meadows National Wildlife Refuge neighboring the Concord River.

11.4% of all households were made up of individuals, and 4.9% had someone living alone who was 65 years of age or older.